Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15802
Title: Molecular mechanisms underlying the regulation of the positioning and formation of the cleavage furrow in cytokinesis in mammalian cells
Authors: ZHU XIAODONG
Keywords: Cytokinesis, Aurora B, Cdc42,
Issue Date: 11-Jun-2009
Source: ZHU XIAODONG (2009-06-11). Molecular mechanisms underlying the regulation of the positioning and formation of the cleavage furrow in cytokinesis in mammalian cells. ScholarBank@NUS Repository.
Abstract: Cytokinesis is the final step of cell division crucial for cell proliferation. It consists of four major steps; cleavage furrow positioning, contractile ring formation, contractile ring contraction and abscission. I have been studying the molecular mechanisms underlying the regulation of cleavage furrow positioning and contractile ring formation by focusing on the functions of a chromosome passenger protein aurora B and a small GTPase Cdc42 using a powerful combination of live-cell imaging techniques and molecular manipulation. I have found that 1) aurora B kinase is required for proper positioning of the cleavage furrow by regulating the microtubule dynamics and 2) Cdc42 regulates the contractile ring formation by stabilizing actin filaments, promoting de novo actin assembly at the equator and cross-talking with the other small GTPase RhoA. In this thesis project, I could make a significant contribution to understanding the mechanisms of cytokinesis in mammalian cells.
URI: http://scholarbank.nus.edu.sg/handle/10635/15802
Appears in Collections:Ph.D Theses (Open)

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