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Title: Comparative analysis of microbial genomes: Architecture and applications
Keywords: microbial genomics, drug targets, computational biology, genome architecture
Issue Date: 22-Jan-2007
Citation: KISHORE RAMAJI SAKHARKAR (2007-01-22). Comparative analysis of microbial genomes: Architecture and applications. ScholarBank@NUS Repository.
Abstract: One of the major incentives behind the genome sequencing of numerous pathogenic bacteria is the desire to better understand their peculiarities and to develop new approaches for controlling human diseases caused by these organisms. This thesis is an attempt to computationally analyze the host-specific adaptations in obligatory intracellular bacteria and develop tools that can facilitate genome analysis towards better understanding of bacterial genome evolution and accelerating computational identification of microbial drug targets. Tools like GOV and PPD were developed for understanding microbial genome design, architecture and the derived knowledge was utilized for understanding of host-specific adaptations in obligatory intracellular parasites. Novel insilico approaches for the identification of putative drug targets in microbial genomes have been designed. Such strategies and their applications enables us to locate critical pathways and steps in pathogenesis at niche and life-style level; and provides clues towards targeting these steps by designing new drugs.
Appears in Collections:Ph.D Theses (Open)

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