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Title: Genomic organization and functional characterization of a novel cancer associated gene - U0-44
Keywords: UO-44, CUB, zona pellucida, cisplatin, RNAi, ovarian cancer
Issue Date: 27-Feb-2007
Source: LEONG TUCK CHOY, CAINE (2007-02-27). Genomic organization and functional characterization of a novel cancer associated gene - U0-44. ScholarBank@NUS Repository.
Abstract: Ovarian cancer is currently the second leading cause of gynecological malignancy and cisplatin or cisplatin-based regimens have been the standard of care for the treatment of advance epithelial ovarian cancers. However, the efficacy of cisplatin treatment is often limited by the development of drug resistance either through the inhibition of apoptotic genes or activation of anti-apoptotic genes. This thesis encompasses the molecular cloning and characterization of a putative oncogene, UO-44. UO-44 (GenBank accession no. AF022147) is an estrogen regulated uterine-ovarian specific complementary DNA that was previously isolated through differential display of a tamoxifen-induced rat uterine cDNA library. The objective of this study is to further examine the role of this gene in the initiation and progression of ovarian cancers.
Appears in Collections:Ph.D Theses (Open)

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