Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15692
Title: Proteomic analysis of airway inflammation in murine asthma models
Authors: ZHAO JING
Keywords: Proteomics, asthma, airway inflammation, bronchoalveolar lavage (BAL), dexamethasone, murine
Issue Date: 7-Feb-2007
Source: ZHAO JING (2007-02-07). Proteomic analysis of airway inflammation in murine asthma models. ScholarBank@NUS Repository.
Abstract: Proteomics studies levels and post-translational modifications of a large number of proteins simultaneously. In this study, we analyzed and quantitated the alterations of global protein expression in bronchoalveolar lavage (BAL) fluid from mice with acute allergic airway inflammation, and BAL fluid together with lung tissue from mice with chronic airway inflammation by employing a proteomics technology. Moreover, we investigated pharmacoproteomics of dexamethasone in an acute allergic mouse asthma model.We have identified many classes of proteins which were for the first time shown to be related to the pathophysiology of asthma. Our findings would shed new light on the exploration of new mechanisms of the development of asthma and identification of potential biomarkers and potential therapeutic targets for asthma. Moreover, our pharmacoproteomics study further broadens our understanding of the spectrum of gene target regulated by steroids and may be useful for the new drug development.
URI: http://scholarbank.nus.edu.sg/handle/10635/15692
Appears in Collections:Ph.D Theses (Open)

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