Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15636
Title: Dissecting the phospholipid signaling pathways triggered by Fc receptors in human immune effector cells
Authors: TAY HWEE KEE
Keywords: FcgRІ, FceRІ, Phospholipase A2, Phospholipase D, Sphingosine kinase, Signaling
Issue Date: 22-Feb-2007
Source: TAY HWEE KEE (2007-02-22). Dissecting the phospholipid signaling pathways triggered by Fc receptors in human immune effector cells. ScholarBank@NUS Repository.
Abstract: Receptors for the constant region of immunoglobulins (FcRs), play a pivotal role in linking up the humoral and cellular arms of the immune system. Upon receptor aggregation, intracellular signaling cascades are triggered via the recruitment and activation of non-receptor tyrosine kinases, leading to the release of potent proinflammatory mediators, including: cytokines, metalloproteases, eicosanoids, histamine, and the oxidative burst. Thus, understanding the intracellular signaling pathways triggered by FcR has profound therapeutic potential. In my study, I have identified novel pathways triggered by FcRs, in immune-effector cells, these include: the identification of the novel calcium-independent Phospholipase A2 (iPLA2), activated by FcgR??, to be responsible for the generation of arachidonic acid and eicosanoids; and the discovery that the Phospholipase D and Sphingosine kinase pathways play important roles in the activation of the transcription factor NF-kB, production of cytokines, eicosanoids and release and activation of matrix metalloproteinases.
URI: http://scholarbank.nus.edu.sg/handle/10635/15636
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