Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15602
Title: Anti-tumor mechanisms of Luteolin, a major Flavonoid oF Chrysanthemum Morifolium
Authors: SHI RANXIN
Keywords: chrysanthemum, luteolin, apoptosis, TNF, TRAIL, cisplatin
Issue Date: 8-Nov-2006
Source: SHI RANXIN (2006-11-08). Anti-tumor mechanisms of Luteolin, a major Flavonoid oF Chrysanthemum Morifolium. ScholarBank@NUS Repository.
Abstract: Luteolin was identified as one of the most abundant components in the chrysanthemum fraction showing the most potent cytotoxicity against human cancer cells. In addition to its anti-tumor effect when used alone, luteolin significantly sensitized TNFI?-induced apoptosis through inhibition of nuclear transcription factor-kappaB and augmentation of c-Jun N-terminal kinase activation. Luteolin also significantly sensitized the apoptosis induced by TRAIL through down-regulation of X-linked inhibitor of apoptosis protein, which was due to enhanced ubiquitination and proteasomal degradation. Furthermore, luteolin was able to enhance the anti-cancer effect of cisplatin through stablization of p53 protein. Finally, the anti-cancer potential of a combination of luteolin and cisplatin was confirmed in a xenograft nude mice model. The evidence from both in vitro and in vivo experiments clearly demonstrates the anti-tumor potential of luteolin as a chemo-sensitizer in cancer therapy.
URI: http://scholarbank.nus.edu.sg/handle/10635/15602
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Shi RX.pdf5.48 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

355
checked on Dec 11, 2017

Download(s)

1,102
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.