Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15601
Title: The function of DTRAF1 in drosophila neuroblast asymmetric cell division
Authors: WANG HUASHAN
Keywords: Drosophila, neuroblast, telophase rescue, DTRAF1, Eiger, asymmetric cell division
Issue Date: 7-Nov-2006
Source: WANG HUASHAN (2006-11-07). The function of DTRAF1 in drosophila neuroblast asymmetric cell division. ScholarBank@NUS Repository.
Abstract: In the past decade, Drosophila melanogaster has been proven to be an excellent model for studying the mechanisms of asymmetric cell division, which generates cell diversity during animal development. In this thesis I analyze telophase rescue in detail in insc mutant NBs and report that DTRAF1 is specifically involved in telophase rescue for the cell fate determinant Mira/Pros but not for Pon/Numb. DTRAF1 is localized to the apical cortex of mitotic NBs and interacts with Baz in vitro. I demonstrate that telophase rescue is compromised when DTRAF1 is removed or delocalized from the apical cortex in various genetic backgrounds. I also show that Eiger, the Drosophila homolog of TNF, is required for telophase rescue. My data provide the first evidence that in Drosophila embryonic CNS, the TNF signal pathway is involved in Mira/Pros telophase rescue.
URI: http://scholarbank.nus.edu.sg/handle/10635/15601
Appears in Collections:Ph.D Theses (Open)

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