Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15537
Title: Roles of angiotensin II receptors on myocardial apoptosis in experimental rat model with ischemia-reperfusion injury
Authors: WANG ZHONGJING
Keywords: Angiotensin-converting-enzyme inhibitor; Angiotensin II receptor antagonists; myocardial apoptosis; myocardial ischemia-reperfusion
Issue Date: 21-Aug-2006
Source: WANG ZHONGJING (2006-08-21). Roles of angiotensin II receptors on myocardial apoptosis in experimental rat model with ischemia-reperfusion injury. ScholarBank@NUS Repository.
Abstract: Myocardial apoptosis has emerged as a predominant mode associated with early stage of left ventricular remodeling and dysfunction after ischemia/reperfusion (I/R) injury. Attenuation of cardiomyocyte apoptosis may be one of the cardioprotective mechanisms by pharmacological interventions in preventing adverse cardiac remodeling and preserving global ventricular function. This thesis was designed to clarify the differential effects of the two Angiotensin II receptor subtypes (AT1R and AT2R) in the modulation of myocardial apoptosis following I/R, with aims on the potential molecular mechanisms underlying the cardiac apoptosis mediated through AT1R and AT2R. The studies show that Ang II-induced cardiomyocyte apoptosis may be associated with the differential activation of both AT1R and AT2R subtypes at transcriptional and translational levels. The intracellular cross-talk between p53 and NF-I?B followed by the modulation of Bcl-2 family members could possibly underlie the observed counteraction between AT1R and AT2R in the settings of cardiac I/R injury.
URI: http://scholarbank.nus.edu.sg/handle/10635/15537
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