Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15520
Title: Nasal polyposis: An immunohistochemical study of cell cycle regulator proteins in epithelial proliferation
Authors: ANG HUI CHI, ANNETTE
Keywords: Nasal polyps, cell cycle regulators
Issue Date: 15-Sep-2006
Source: ANG HUI CHI, ANNETTE (2006-09-15). Nasal polyposis: An immunohistochemical study of cell cycle regulator proteins in epithelial proliferation. ScholarBank@NUS Repository.
Abstract: Nasal polyposis, a multifactorial disease of the nasal mucosa, is characterised clinically by the presence of oedematous masses in the nasal and paranasal cavities. The precise pathogenetic mechanisms of nasal polyposis are not clearly understood. Twenty-five specimens of nasal polyp mucosa and 10 specimens of non-polypoidal inferior turbinate mucosa, were investigated using immunohistochemistry for the immunostaining of Ki-67, p21, p27, p53 and p63. Comparison between the 2 groups was performed using 2-sample t-test. Multiple regression of each immunolabelling indexes (p21, p27, p53 and p63) vs. proliferation (Ki67) index was analysed. We detected a statistically significant higher proliferation index in polypoidal mucosa. The expression of cell cycle proteins p21, p27 and p63 were significantly decreased as compared to that of non-polypoidal mucosa. Using multiple regression, we confirmed that the assessment of p21 and p27 immunolabelling indexes together, is a useful predictor of Ki67 activity (increased proliferation) in nasal polyps.
URI: http://scholarbank.nus.edu.sg/handle/10635/15520
Appears in Collections:Master's Theses (Open)

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