Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15456
Title: Studies of the anti-metastatic potential of emodin on human tumor cells
Authors: HUANG QING
Keywords: emodin; cancer; metastasis; invasion; migration; adhesion
Issue Date: 28-Aug-2006
Source: HUANG QING (2006-08-28). Studies of the anti-metastatic potential of emodin on human tumor cells. ScholarBank@NUS Repository.
Abstract: Tumor metastasis is a complex process that involves several interdependent events: angiogenesis, adhesion, migration and invasion. Identification of potential agents that effectively act to interrupt various steps of metastatic cascade could be of great clinical significance. In this study, the anti-metastatic property of emodin, an active component from the rhizome of Rheum palmatum, has been systematically clarified: first, emodin inhibits the invasiveness of human cancer cells by suppressing matrix metalloproteinase-9 expression through inhibition of activator protein-1 and nuclear factor kappaB signaling; Second, emodin suppresses tumor cell migration through phosphatidylinositol 3-kinase-Cdc42/Rac1 signaling pathway; Third, emodin inhibits cancer cell adhesion through cholesterol reduction in the membrane lipid rafts and subsequent disruption of the lipid rafts-associated integrin signaling. These findings suggest that emodin interferes with tumor metastasis at several pivotal points and it could be of therapeutic value in preventing metastasis of human cancers.
URI: http://scholarbank.nus.edu.sg/handle/10635/15456
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