Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15404
Title: Fabrication of core-shell nanoparticles and nanoporous membrane for anticancer drug delivery
Authors: WEI JIASHEN
Keywords: temperature- and pH-sensitive, nanoparticles, silicon nitride, stress controlled, nanoporous membrane, anticancer drug delivery
Issue Date: 29-Jun-2006
Source: WEI JIASHEN (2006-06-29). Fabrication of core-shell nanoparticles and nanoporous membrane for anticancer drug delivery. ScholarBank@NUS Repository.
Abstract: This thesis presents the development of core-shell nanoparticles as delivery vehicles and SiNx nanoporous membranes as releasing devices for large size nanoparticles in anticancer drug delivery. Firstly, the temperature- and pH-sensitive amphiphilic polymer poly(N-isopropylacrylamide-co-acrylic acid-co-cholesteryl acrylate) (P(NIPAAm-co-AA-co-CHA)) has been synthesized and employed to encapsulate anticancer drug: paclitaxel, in core-shell nanoparticles. By characterizing the paclitaxel loaded nanoparticles, including their morphology, stability, LCST, CAC, encapsulation efficiency, in vitro release and cytotoxicity, it was found these temperature- and pH-sensitive nanoparticles would be a promising carrier for intracellular delivery of anticancer drugs.To solve the delivery difficulties of large size nanoparticles, a near zero residual stress SiNx layer deposited by optimized PECVD processes in high power and high frequency has been developed, and the nanoporous membrane fabricated by zero stress SiNx layers with pore size of 400 nm has been successfully achieved. This nanoporous membrane was approved to be biocompatible by cell culture experiments.
URI: http://scholarbank.nus.edu.sg/handle/10635/15404
Appears in Collections:Master's Theses (Open)

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Title Page.pdf6.54 kBAdobe PDF

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Acknowledgements.pdf9.09 kBAdobe PDF

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Table of Contents.pdf13.58 kBAdobe PDF

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Summary.pdf13.69 kBAdobe PDF

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List of Tables.pdf7.23 kBAdobe PDF

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List of Schemes.pdf7.48 kBAdobe PDF

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List of Figures.pdf75.86 kBAdobe PDF

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Chapter 1 Introduction.pdf439.31 kBAdobe PDF

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Chapter 2 Temperature and pH Sensitive Core Shell Nanoparticles.pdf525.23 kBAdobe PDF

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Chapter 3 Nanoporous Membrane Fabricated by Stress Controlled SiNx.pdf374.6 kBAdobe PDF

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Chapter 4 Conclusions and Recommendation.pdf12.62 kBAdobe PDF

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References.pdf51 kBAdobe PDF

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