Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15308
Title: Exploring the brain-gut axis in irritable bowel syndrome: Specific emphasis on stress and melatonin
Authors: SONG GUANGHUI
Keywords: brain-gut axis, irritable bowel syndrome, stress, melatonin, sleep disturbance, pain
Issue Date: 17-Apr-2006
Source: SONG GUANGHUI (2006-04-17). Exploring the brain-gut axis in irritable bowel syndrome: Specific emphasis on stress and melatonin. ScholarBank@NUS Repository.
Abstract: Stress can influence brain and bowel functions causing dysregulation of brain-gut axis in irritable bowel syndrome (IBS). Melatonin, a pineal hormone, could have many functions on brain-gut axis and IBS related symptoms. Thus, a series of animal and human studies were done in the present thesis to investigate the brain-gut axis and put specific emphases on stress and melatonin in IBS. The results showed stress changed gut function in rats and human. Dysfunctional central pain modulating mechanisms under stress conditions were observed in IBS patients compared with healthy controls. Furthermore, in rat, melatonin significant alleviated stress induced defecation. In IBS patients, melatonin attenuated abdominal pain and increase rectal pain threshold despite the absence of improvements in sleep disturbance and psychological distress. These findings suggested that stress plays an important in the dysregulation of brain-gut axis, thus could causing IBS. Moreover, melatonin could be a promising candidate for the treatment of IBS.
URI: http://scholarbank.nus.edu.sg/handle/10635/15308
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
01 Song Guanghui_ thesis title.pdf7.04 kBAdobe PDF

OPEN

NoneView/Download
02 Song Guanghui_thesis content.pdf161.59 kBAdobe PDF

OPEN

NoneView/Download
03 Song Guanghui_thesis main body.pdf1 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

348
checked on Dec 18, 2017

Download(s)

895
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.