Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15269
Title: Part I - Synthesis of photochromic fulgides Part II - Synthetic studies towards anti-SARS agent AG7088
Authors: LEE WEI WOON, WAYNE
Keywords: Photochromic, Fulgide, Fulgimide, microwave synthesis, anti-SARS, AG7088.
Issue Date: 11-May-2006
Source: LEE WEI WOON, WAYNE (2006-05-11). Part I - Synthesis of photochromic fulgides Part II - Synthetic studies towards anti-SARS agent AG7088. ScholarBank@NUS Repository.
Abstract: Herein we report the design and synthesis of several photochromic fulgides, including a new class of fulgides a?? the Cycloalkylidene fulgides. The photochromic properties of the new fulgides were also investigated. Furthermore, the development of a new methodology towards the synthesis of the imide derivatives of the fulgides have been developed and optimized. Accomplishments include the reduction in the use of organic solvents as well as shorter reaction times used for the reactions. Our synthetic studies towards the synthesis of anti-SARS agent AG7088 led us to the discovery of a novel methodology involving the application of indium-mediated allylation as a key step towards a key intermediate. Our study included the synthesis of 2 key fragments, towards the synthesis of AG7088.
URI: http://scholarbank.nus.edu.sg/handle/10635/15269
Appears in Collections:Ph.D Theses (Open)

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