Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15039
Title: Chemistry of Southeast Asian plants
Authors: LE CONG THUAN
Keywords: Celastraceae, Salasia chinensis, Hepaticae, Pallavicinia lyellii, diterpenoid, bis bibenzyl, nociceptin receptor
Issue Date: 15-Jan-2006
Source: LE CONG THUAN (2006-01-15). Chemistry of Southeast Asian plants. ScholarBank@NUS Repository.
Abstract: From the stem bark of Salacia chinensis L. collected in Vietnam, eight triterpenoids were isolated, including one new natural product.Phytochemical studies has shown that the liverwort Pallavicinia lyellii may have two chemotypes: one chemotype can produce bis bibenzyls (type I a?? collected in Singapore), while the other one does not have that capability (type II a?? collected in Vietnam). This is the first report of the isolation of bis bibenzyls in the family Pallaviciniaceae. Both chemotypes, however, biosynthesized a number of complex modified labdane diterpenoids. Type II P. lyellii can produce Diels-Alder cycloaddition type dimeric diterpenoids. This is also the first report of 2-oxygenated labdane diterpenoid in liverworts.Bioassays screening for nociceptin receptor (NOP) ligand revealed that the crude extract of the Vietnamese P. lyellii has higher binding affinity to NOP than the endogenous ligand OFQ/N. Further investigation is needed in order to identify the potential NOP ligand from this liverwort.
URI: http://scholarbank.nus.edu.sg/handle/10635/15039
Appears in Collections:Ph.D Theses (Open)

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