Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.neurobiolaging.2016.09.022
Title: | Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study | Authors: | Wang L. Heckman M.G. Aasly J.O. Annesi G. Bozi M. Chung S.J. Clarke C. Crosiers D. Eckstein G. Garraux G. Hadjigeorgiou G.M. Hattori N. Jeon B. Kim Y.J. Kubo M. Lesage S. Lin J.J. Lynch T. Lichtner P. Mellick G.D. Mok V. Morrison K.E. Quattrone A. Satake W. Silburn P.A. Stefanis L. Stockton J.D. Tan E.K. Toda T. Brice A. Van Broeckhoven C. Uitti R.J. Wirdefeldt K. Wszolek Z. Xiromerisiou G. Maraganore D.M. Gasser T. Krüger R. Farrer M.J. Ross O.A. Sharma M. |
Keywords: | Genetic epidemiology LRRK2 PARK16 Parkinson's disease |
Issue Date: | 2017 | Publisher: | Elsevier | Citation: | Wang L., Heckman M.G., Aasly J.O., Annesi G., Bozi M., Chung S.J., Clarke C., Crosiers D., Eckstein G., Garraux G., Hadjigeorgiou G.M., Hattori N., Jeon B., Kim Y.J., Kubo M., Lesage S., Lin J.J., Lynch T., Lichtner P., Mellick G.D., Mok V., Morrison K.E., Quattrone A., Satake W., Silburn P.A., Stefanis L., Stockton J.D., Tan E.K., Toda T., Brice A., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M., Gasser T., Krüger R., Farrer M.J., Ross O.A., Sharma M. (2017). Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging 49 : 217.e1-217.e4. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2016.09.022 | Abstract: | A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. © 2016 Elsevier Inc. | Source Title: | Neurobiology of Aging | URI: | http://scholarbank.nus.edu.sg/handle/10635/150221 | ISSN: | 1974580 | DOI: | 10.1016/j.neurobiolaging.2016.09.022 |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
j.neurobiolaging.2016.09.022.pdf | 46.36 kB | Adobe PDF | OPEN | Pre-print | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.