Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14968
Title: Study of drug release behaviour from HPMC matrix tablets and EC coated matrix reservoir system
Authors: LI XIAOMAN
Keywords: matrix tablets, HPMC, EC coating, reservoir system, particle size, coating level
Issue Date: 31-Oct-2005
Source: LI XIAOMAN (2005-10-31). Study of drug release behaviour from HPMC matrix tablets and EC coated matrix reservoir system. ScholarBank@NUS Repository.
Abstract: In monolithic matrix systems, particle size properties of the controlled release polymer, HPMC, had significant impact on drug release performance. The rate of drug released from the matrix tablet generally decreased as the mean particle size of HPMC was reduced. The drug release mechanism was affected by HPMC mean particle size and concentration. Drug release constant was proportionally related to polymer mean particle size and relative number of polymer particles in the matrix system.The release performance of naproxen sodium and aspirin from EC coated HPMC matrices was studied. The release of aspirin was more sensitive to EC coating level, while that of naproxen sodium was influenced more significantly by HPMC content in the core. Application of EC coating suppressed drug release rate and the magnitude of suppression was dependent on the coating thickness and soluble additive concentration.
URI: http://scholarbank.nus.edu.sg/handle/10635/14968
Appears in Collections:Master's Theses (Open)

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