Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.parkreldis.2005.04.007
Title: Non-motor manifestations in essential tremor: Use of a validated instrument to evaluate a wide spectrum of symptoms
Authors: Tan E.K. 
Fook-Chong S. 
Lum S.Y.
Gabriel C.
Koh K.K.
Prakash K.M. 
Louis E.D.
Keywords: Essential tremor
Psychopathology
SCL-90R
Severity
Issue Date: 2005
Citation: Tan E.K., Fook-Chong S., Lum S.Y., Gabriel C., Koh K.K., Prakash K.M., Louis E.D. (2005). Non-motor manifestations in essential tremor: Use of a validated instrument to evaluate a wide spectrum of symptoms. Parkinsonism and Related Disorders 11 (6) : 375-380. ScholarBank@NUS Repository. https://doi.org/10.1016/j.parkreldis.2005.04.007
Abstract: Introduction: Recent studies suggest an association between non-motor symptoms and essential tremor (ET). Few studies have assessed psychological symptoms in ET. These studies were limited to western white populations and utilized scales that were specific to only one or two psychiatric domains. By contrast, the Symptom Checklist-90R (SCL-90R) is a validated clinical scale to screen for symptoms related to a spectrum of nine different psychological domains. Objective: To determine whether a wide spectrum of non-motor manifestations is associated with ET in patients in an Asian cohort. Methods: Consecutive ET patients and a group of control subjects were evaluated using the SCL-90R, which is comprised of items in nine major symptom dimensions and three global indices, including the positive symptom distress index. Results: ET patients (N=84) and controls (N=78) were similar in age (50.0±18.0 vs 46.0±14.4 years), gender and other demographic variables. ET patients had higher scores in three of nine major symptom dimensions: anxiety, phobic anxiety (p<0.0005) and psychoticism (p=0.005). In multivariate analysis, the anxiety (p<0.0005) and the positive symptom distress index scores (p<0.0005) were greater in ET patients compared to controls after adjusting for sex, age, marital status and educational level. The severity, but not duration of ET was correlated with the severity of anxiety symptoms. Conclusions: Utilizing the SCL-90R, we highlighted that ET patients reported more non-motor symptoms than healthy controls. The more frequent occurrence of anxiety symptoms in our Asian cohort extends the observation that such non-motor manifestations should be considered in the clinical management of ET. © 2005 Elsevier Ltd. All rights reserved.
Source Title: Parkinsonism and Related Disorders
URI: http://scholarbank.nus.edu.sg/handle/10635/149653
ISSN: 13538020
DOI: 10.1016/j.parkreldis.2005.04.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
NonMotor.j.parkreldis.2005.04.007.pdf96.64 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

45
checked on Jan 23, 2019

WEB OF SCIENCETM
Citations

39
checked on Dec 31, 2018

Page view(s)

13
checked on Jan 17, 2019

Download(s)

9
checked on Jan 17, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.