Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.scr.2016.12.010
| Title: | Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T | Authors: | Ma D. Ng S.H. Zeng L. Zhao Y. Tan E.K. |
Issue Date: | 2017 | Publisher: | Elsevier B.V. | Citation: | Ma D., Ng S.H., Zeng L., Zhao Y., Tan E.K. (2017). Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T. Stem Cell Research 18 : 54-56. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2016.12.010 | Abstract: | Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with S1647T variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus reprogramming system. The transgene-free iPSC showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This cellular model will be useful for further function studies and therapeutic screening. � 2016 The Authors | Source Title: | Stem Cell Research | URI: | http://scholarbank.nus.edu.sg/handle/10635/149000 | ISSN: | 18735061 | DOI: | 10.1016/j.scr.2016.12.010 |
| Appears in Collections: | Elements Staff Publications |
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