Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14862
Title: Novel biodegradable cationic core-shell nanoparticles for codelivery of drug and DNA
Authors: WANG YONG
Keywords: gene delivery; codelivery of drug and gene; cationic amphiphilic copolymer; synergistic effect;cationic micelles
Issue Date: 8-Aug-2005
Source: WANG YONG (2005-08-08). Novel biodegradable cationic core-shell nanoparticles for codelivery of drug and DNA. ScholarBank@NUS Repository.
Abstract: Codelivery of drug and gene can improve gene transfection efficiency and achievesynergy of drug and gene therapies. The aim of this study is to develop cationic core-shellstructured micelles to carry drug and gene simultaneously. A series of biodegradablecationic amphiphilic copolymers have been developed, which can self-assemble intomicelles. Model drug compounds have been encapsulated into the core of the micelles.The luciferase expression level in various cell lines, mediated by the cationic micelles,was comparable to that provided by PEI. However, the percentage of GFP-positive cellsachieved by the micelles was higher. Codelivery of cyclosporine A or paclitaxel with theluciferase reporter gene was found to enhance gene expression. Successful genetransfection was achieved in the cochlear of guinea pigs and tumor-bearing mice. Thesecationic micelles may make a promising non-viral gene carrier and may provide a uniqueapproach to carry drug and gene simultaneously in order to achieve synergy of drug andgene therapies.
URI: http://scholarbank.nus.edu.sg/handle/10635/14862
Appears in Collections:Ph.D Theses (Open)

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Acknowledgements.pdf7.56 kBAdobe PDF

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Table of Contents.pdf19.81 kBAdobe PDF

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Summary.pdf21.77 kBAdobe PDF

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List of Schemes, Tables and Figures.pdf48.78 kBAdobe PDF

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List of Abbreviations.pdf24.04 kBAdobe PDF

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Chapter 1 Introduction.pdf30.46 kBAdobe PDF

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Chapter 2 Literature Review.pdf166.77 kBAdobe PDF

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Chapter 3 Materials and Experimental Methods.pdf106.76 kBAdobe PDF

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Chapter 4 Results and Discussion.pdf10.86 MBAdobe PDF

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Chapter 5 Conclusions and Recommendations.pdf35.95 kBAdobe PDF

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References.pdf84.04 kBAdobe PDF

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Patent & and Publications Derived From This Thesis.pdf5.35 kBAdobe PDF

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