Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14821
Title: Modulation of dorsal hippocampus field CA1 pyramidal cell excitability by an ascending relay from hypothalamic supramammillary nucleus
Authors: JIANG FENGLI
Keywords: anaesthetized rat, pyramidal cell, medial septum, neural inactivation, supramammillary region, theta waves
Issue Date: 6-Jun-2005
Source: JIANG FENGLI (2005-06-06). Modulation of dorsal hippocampus field CA1 pyramidal cell excitability by an ascending relay from hypothalamic supramammillary nucleus. ScholarBank@NUS Repository.
Abstract: Experiments were performed on the urethane anaesthetized rat to test the hypothesis that theta generating reticular stimulation affected the excitability of CA1 pyramidal cells. In this context, it was observed that reticular stimulation induced a suppression of the CA1 pyramidal cell population spike and the corresponding dendritic field excitatory postsynaptic potential evoked by field CA3 stimulation. However, this suppression was observed at stimulation intensity below the threshold for generation of CA1 theta and was maximal at the threshold for theta. The frequency and amplitude of theta waves, by contrast, increased further with increasing reticular stimulation voltage suggesting dissociation between mechanisms underlying suppression and theta generation. Further studies involving reversible neural inactivation with local microinjection of drugs indicated that the reticularlya??elicited suppression was mediated by neural substrate(s) in the medial supramammillary region and the medial septum. Interestingly, cholinergic mechanisms in the lateral supramammillary region evoked CA1 suppression also via the medial septum.
URI: http://scholarbank.nus.edu.sg/handle/10635/14821
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
combined thesis text for submission to shool.pdf2.06 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

191
checked on Jan 19, 2018

Download(s)

151
checked on Jan 19, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.