Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/147862
Title: ENVIRONMENTAL APPLICATIONS OF EARTHWORM METABOLOMICS
Authors: WANG LEI
Keywords: toxicology,vermifiltration,tributyl phosphate,triphenyl phosphate,nuclear magnetic resonance,mass spectrometry
Issue Date: 10-May-2018
Citation: WANG LEI (2018-05-10). ENVIRONMENTAL APPLICATIONS OF EARTHWORM METABOLOMICS. ScholarBank@NUS Repository.
Abstract: This thesis aims to understand earthworm Perionyx excavatus biochemistry in environmental processes using metabolomics. In chapter 2, 1H NMR metabolomics revealed that earthworms underwent increasing and then decreasing metabolic activity in continuous vermifiltration for two months. In chapter 3 and 4, the metabolism and toxicity of two industrial chemicals tri-n-butyl phosphate and triphenyl phosphate in earthworms were investigated by GC-MS and LC-QTOF. Novel phase II conjugations were identified: phosphate conjugations and thiols conjugations. Significant perturbations in endogenous metabolome were found only after acute exposure. Overall, these applications offered unprecedented insights in vermifilter operation and xenobiotics detoxification in P. excavatus.
URI: http://scholarbank.nus.edu.sg/handle/10635/147862
Appears in Collections:Ph.D Theses (Open)

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