Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14762
Title: Construction of nerve growth factor loop 4 - containing polypeptides for facilitated gene transfer to neurons
Authors: ZENG JIEMING
Keywords: nerve growth factor; TrkA; gene delivery; polypeptide; nonviral vector; neurons
Issue Date: 23-Jun-2005
Source: ZENG JIEMING (2005-06-23). Construction of nerve growth factor loop 4 - containing polypeptides for facilitated gene transfer to neurons. ScholarBank@NUS Repository.
Abstract: Targeted gene delivery to diseased subtypes of neurons will benefit the success of gene therapy to neurological disorders. This study has demonstrated that an NGF loop 4-containing hairpin motif, either chemically synthesized or bacterially produced recombinant one, can function as a novel ligand for targeted gene delivery. The motif can bind to TrkA, mediate in vitro gene transfer via TrkA with efficiency, and has shown potential targeting ability for in vivo gene delivery to neurons without toxicity. The study provides, for the first time, an example for targeted gene delivery to a subtype of neurons and presents a platform to build more sophisticated TrkA-targeted vectors by incorporating other functional domains.
URI: http://scholarbank.nus.edu.sg/handle/10635/14762
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