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Title: Effects of proteasome inhibition on neuronal cells
Keywords: proteasome, heat shock protein, neurodegenerative disease, microarray, lactacystin
Issue Date: 31-May-2005
Citation: YEW HAU JIN, ELAINE (2005-05-31). Effects of proteasome inhibition on neuronal cells. ScholarBank@NUS Repository.
Abstract: The inhibition of the ubiquitin proteasome system (UPS) has been postulated to play a key role in the pathogenesis of neurodegenerative diseases. Studies have also shown that proteasome inhibition can induce a neuroprotective rise in the levels of various heat shock proteins (HSPs). This study examines the global gene expression of primary neurons in response to treatment with the proteasome inhibitor, lactacystin and identifies differentially expressed genes that may play a role in the regulation of proteasome inhibitor-mediated apoptosis. Our results suggest an initial neuroprotective pathway involving HSPs, antioxidants and cell cycle inhibitors, followed by a pro-apoptotic response mediated by inflammation, oxidative stress and possibly, aberrant activation of cell cycle proteins. Further studies were carried out to investigate the role of selected differentially expressed genes in the regulation of neuronal apoptosis. These include a heat shock protein, heat shock protein 22, annexin A3 and a novel gene, neoplastic progression 3.
Appears in Collections:Master's Theses (Open)

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