Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14712
Title: Association study of ABCA1 polymorphisms in Singapore populations
Authors: TAN HUI HUI, JENNY
Keywords: ABCA1, Genetic association, Coronary artery disease, HDL-C, SNPs, Singapore
Issue Date: 14-Jul-2005
Source: TAN HUI HUI, JENNY (2005-07-14). Association study of ABCA1 polymorphisms in Singapore populations. ScholarBank@NUS Repository.
Abstract: The goal of the study was to assess whether common genetic variations in the ATP binding cassette transporter (ABCA1) gene contribute to inter-individual variation in coronary artery disease (CAD) susceptibility and plasma lipid concentrations among Singapore Chinese, Malay and Indian males. Thirty-two ABCA1 genetic variants were identified sing denaturing high performance liquid chromatography, EST data and resequencing. Seven ABCA1 SNPs (-14C>T, 237indelG, R219K, V825I, M883I, IVS44+18C>T and 8995A>G) were evaluated for their associations with the CAD trait as well as mean high-density lipoprotein-cholesterol, apolipoprotein-AI and triglyceride concentrations. The results support the role of common ABCA1 genetic variation in modulating CAD susceptibility and plasma lipid levels in an ethnic-dependent manner. But other reasons such as varying power, underlying differences in genetic and non-genetic background, chance findings due to multiple testing and population stratification may also be evoked to explain these ethnic-specific effects and further studies are necessary to validate the findings.
URI: http://scholarbank.nus.edu.sg/handle/10635/14712
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01 Table of Contents.pdf41.72 kBAdobe PDF

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02 Chap 1 Intro.pdf13.37 kBAdobe PDF

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03 Chap 2 Lit review I.pdf147.69 kBAdobe PDF

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04 Chap 3 Lit review II.pdf52.94 kBAdobe PDF

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05 Chap 4 Materials and Methods.pdf605.61 kBAdobe PDF

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06 Chap 5 SNP Survey.pdf1.42 MBAdobe PDF

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06 Chap 6 Genetic Association.pdf2.65 MBAdobe PDF

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07 References.pdf75.28 kBAdobe PDF

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