Please use this identifier to cite or link to this item:
|Title:||Screening for asymptomatic bacteruria at one month after adult kidney transplantation: Clinical factors and implications|
urinary tract infection
|Publisher:||Blackwell Publishing Ltd|
|Citation:||Goh Y.S.B., Deng Z., Cheong P.S.C., Raman L., Goh T.H.A., Vathsala A., Tiong H.Y. (2017-05-01). Screening for asymptomatic bacteruria at one month after adult kidney transplantation: Clinical factors and implications. Clinical Transplantation 31 (5) : e12954. ScholarBank@NUS Repository. https://doi.org/10.1111/ctr.12954|
|Abstract:||Objective: Urinary tract infections (UTIs) account for significant morbidity after kidney transplantation (KT). Screening for asymptomatic bacteruria (AB) has proven to be beneficial in certain population including pregnant women; however, it is not well-studied in KT population. We reviewed the incidence, clinical features, and implications of asymptomatic bacteruria one month after KT. Methods: A total of 171 adult KT patients (86 [50.3%] living transplants, 87 [50.9%] males, mean age 47.3���13.7�years), between 2005 and 2012, were analyzed. Immunosuppression induction and maintenance were as per protocol. Protocol urine cultures were taken at 1�month post-transplantation. Patients were stratified for presence of AB and analyzed for demographics and clinical parameters. Outcomes of hospitalization for symptomatic UTIs, graft, and patient survival were ascertained. Results: Forty-one (24%) KT recipients had AB at 30�days post-transplant. Multiresistant organisms accounted for 43.9% of these infections. Logistic regression confirms female sex and deceased donor recipients as independent predictors of 30-day bacteruria, which predicts subsequent hospitalization for symptomatic UTI. One-year patient and graft survival were similar in recipient with or without AB. Conclusion: Asymptomatic bacteruria 30�days post-transplant can be predicted in female recipients and kidneys from deceased donors probably due to anatomical and functional differences respectively. There is increased morbidity of subsequent hospitalization for symptomatic UTI and more research in prevention of UTI is needed, particularly non-antibiotic prophylaxis. � 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd|
|Source Title:||Clinical Transplantation|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 17, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.