Please use this identifier to cite or link to this item: https://doi.org/10.1038/nature22795
Title: Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
Authors: McGovern N.
Shin A.
Low G.
Low D.
Duan K.
Yao L.J.
Msallam R.
Low I.
Shadan N.B.
Sumatoh H.R.
Soon E.
Lum J.
Mok E.
Hubert S.
See P.
Kunxiang E.H.
Lee Y.H.
Janela B.
Choolani M.
Mattar C.N.Z.
Fan Y.
Lim T.K.H.
Chan D.K.H.
Tan K.-K. 
Tam J.K.C. 
Schuster C.
Elbe-B�rger A.
Wang X.-N.
Bigley V.
Collin M.
Haniffa M.
Schlitzer A.
Poidinger M.
Albani S.
Larbi A.
Newell E.W.
Chan J.K.Y.
Ginhoux F.
Issue Date: 29-Jun-2017
Publisher: Nature Publishing Group
Citation: McGovern N., Shin A., Low G., Low D., Duan K., Yao L.J., Msallam R., Low I., Shadan N.B., Sumatoh H.R., Soon E., Lum J., Mok E., Hubert S., See P., Kunxiang E.H., Lee Y.H., Janela B., Choolani M., Mattar C.N.Z., Fan Y., Lim T.K.H., Chan D.K.H., Tan K.-K., Tam J.K.C., Schuster C., Elbe-B�rger A., Wang X.-N., Bigley V., Collin M., Haniffa M., Schlitzer A., Poidinger M., Albani S., Larbi A., Newell E.W., Chan J.K.Y., Ginhoux F. (2017-06-29). Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 546 (7660) : 662-666. ScholarBank@NUS Repository. https://doi.org/10.1038/nature22795
Abstract: During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-? production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation. � 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Source Title: Nature
URI: http://scholarbank.nus.edu.sg/handle/10635/146685
ISSN: 00280836
DOI: 10.1038/nature22795
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Sep 17, 2018

Page view(s)

11
checked on Sep 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.