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Title: Nanoencapsulation of quantum dot nanoparticles in biological labeling
Keywords: Quantum dots; Nanoparticles; Polystyrene; Surface modification; folic acid; intracellular delivery
Issue Date: 13-Apr-2005
Source: HUANG NING (2005-04-13). Nanoencapsulation of quantum dot nanoparticles in biological labeling. ScholarBank@NUS Repository.
Abstract: Quantum Dots (QDs) have attracted considerable interest in luminescence tagging due to their unique optical and electronic properties. The ideal optical properties of QDs offer the possibility of using them as fluorescent probes in biological staining and diagnostics. But some problems associated with QDs, for example, poor water solubility, poor biocompatibility and chemical stability in physiological media, limit their use in biomedical applications. Though some efforts have been made to prepare QD-tagged microbeads, the sizes of the beads are above 100nm, which make them not suitable for labeling of subcellular components. In this work, fluorescent QDs were incorporated into polystyrene nanoparticles using emulsion polymerization method and particle sizes were controlled. The nanoparticles have carboxyl groups on the surfaces that can be used for further attachment of biomolecules. After surface modification with folic acid, the intracellular delivery of the nanoparticles into NIH-3T3 and HT-29 cells was investigated using confocal microscope.
Appears in Collections:Master's Theses (Open)

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