Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14551
Title: Studies on pain management: Preemptive analgesia and traditional Chinese medicine (TCM)
Authors: CHOO SHIOK SHYAN
Keywords: pain management, preemptive analgesia, post-incisional pain, Traditional Chinese Medicine (TCM), etoricoxib, tramadol
Issue Date: 3-Jan-2005
Source: CHOO SHIOK SHYAN (2005-01-03). Studies on pain management: Preemptive analgesia and traditional Chinese medicine (TCM). ScholarBank@NUS Repository.
Abstract: The focus of our research is on pain management from two perspectives: (1) Assessment of a??preemptive analgesiaa?? for postoperative pain in an animal model and a clinical study; (2) Survey of the use of Traditional Chinese Medicine (TCM) for pain management in Singapore. The preemptive analgesic effects of etoricoxib, celecoxib, indomethacin, naproxen and tramadol were studied in a rat model of post-incisional pain. Preoperative administration of these drugs exhibited significantly higher withdrawal thresholds than that of the placebo and postoperative group (except celecoxib). The analgesic efficacies and safety profiles of preoperative rofecoxib and tramadol were compared in patients undergoing haemorrhoidectomies. They showed comparable analgesic efficacies, but tramadol was associated with higher incidence of side-effects. The questionnaire survey revealed that the prevalence of TCM used for pain was approximately 47%, and 46.5% of them used TCM as the first-line treatment. This suggested that TCM plays a significant role in pain management.
URI: http://scholarbank.nus.edu.sg/handle/10635/14551
Appears in Collections:Master's Theses (Open)

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