Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14529
Title: Genetic epidemiology of coronary artery disease
Authors: SUMAN LAL CHIRAMMAL SUGUNAN
Keywords: Coronary Artery Disease, Ethnic Variation
Issue Date: 1-Feb-2005
Source: SUMAN LAL CHIRAMMAL SUGUNAN (2005-02-01). Genetic epidemiology of coronary artery disease. ScholarBank@NUS Repository.
Abstract: Polymorphisms in the GlycoproteinIIIa PIA1/A2, FactorXIII(V34L) and mitochondrial(5178C>A) genes were investigated in relation to coronary artery disease(CAD) among the Chinese, Malay and Indian ethnic groups in Singapore. The genotypic distribution of the three polymorphisms was in accordance to a population at Hardy Weinberg equilibrium. The GpIIIa PIA2allele has a significantly higher frequency among Indians relative to the Chinese and Malays; the possible association of the PIA2 allele among Indians with CAD is independent of the effects of smoking. The FactorXIII L34 allele is significantly higher among the Asian Indians than the Chinese and Malays and the mean FXIII levels are significantly higher among the Asian Indians when compared to the Chinese. The polymorphism explains 13% of the total variation of FXIII activity among the female Indians. The mtDNA 5178C>A polymorphism is associated, in an ethnic group and gender-specific manner with plasma apoB levels in the Singaporean Chinese males.
URI: http://scholarbank.nus.edu.sg/handle/10635/14529
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