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Title: Molecular mechanisms involved in the specification of embryonic ectoderm in the zebrafish embryo
Keywords: Neural induction, cell adhesion, zebrafish, Frizzled-7, Frizzled-2, beta-catenin.
Issue Date: 15-Dec-2004
Source: FONG HAW TIEN (2004-12-15). Molecular mechanisms involved in the specification of embryonic ectoderm in the zebrafish embryo. ScholarBank@NUS Repository.
Abstract: During gastrulation, optimal adhesion and receptivity to signalling cues are essential for cells to acquire new positions and identities via coordinated cell movements. T-box transcription factors and the Wnt signalling pathways play important roles in these processes. Here we show that Tbx2b is required cell-autonomously for cell adhesion and cell movement in the embryonic ectoderm, where it acts within the context of Fz7 via components of canonical Wnt pathway during the formation of the neural plate. We also show that FGF signalling does not play a role in this process, in contrast to studies in amniotes. We in addition fate-mapped previously undefined population of deep lying cells in the zebrafish blastula, and show that Fz2 function is essential for their migration to the ventral gastrula and thus the future posterior structures of the embryo. These results provide insights into the molecular mechanisms underlying the specification of the embryonic ectoderm in the zebrafish.
Appears in Collections:Ph.D Theses (Open)

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