Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/143285
Title: CONFORMATIONAL CHANGES OF SINGLE DNA MOLECULES INDUCED BY HFQ AND PROTAMINE
Authors: JIANG KAI
Keywords: nanofluidic,Hfq,protamine,DNA,DNA-protein binding,single molecule study
Issue Date: 20-Jan-2016
Citation: JIANG KAI (2016-01-20). CONFORMATIONAL CHANGES OF SINGLE DNA MOLECULES INDUCED BY HFQ AND PROTAMINE. ScholarBank@NUS Repository.
Abstract: SINGLE MOLECULE TECHNIQUES ARE NOWADAYS ROUTINELY EMPLOYED FOR INVESTIGATING THE PROPERTIES OF BIOMACROMOLECULES. ADVANCES IN NANOFABRICATION HAVE MADE IT POSSIBLE TO FABRICATE QUASI ONE-DIMENSIONAL CHANNEL DEVICES WITH CROSS-SECTIONAL DIAMETERS IN THE RANGE OF TENS TO HUNDREDS OF NANOMETERS. THESE CHANNELS SERVE AS A PLATFORM FOR STUDYING SINGLE DNA MOLECULES. ADVANTAGES OF THE NANOCHANNEL PLATFORM ARE THAT THE DNA MOLECULES ARE IN AN EQUILIBRIUM CONFORMATION, HIGH THROUGH-PUT CAN BE ACHIEVED BY USING ARRAYS OF PARALLEL CHANNELS AND INTEGRATION WITH LAB-ON-CHIP DEVICES. THIS THESIS FOCUS ON THE CONFORMATIONAL CHANGES OF SINGLE DNA MOLECULES INDUCED BY HFQ AND PROTAMINE BY USING SINGLE MOLECULE TECHNIQUES.
URI: http://scholarbank.nus.edu.sg/handle/10635/143285
Appears in Collections:Ph.D Theses (Open)

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