Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/143281
Title: INTESTINAL MICROBIOTA IN EARLY LIFE AND ITS ASSOCIATION WITH ALLERGY DEVELOPMENT
Authors: JUNE LOW SU YIN
Keywords: allergy, intestinal microbiota, gut microbiota, infants, early life, biomarkers
Issue Date: 7-Jan-2016
Citation: JUNE LOW SU YIN (2016-01-07). INTESTINAL MICROBIOTA IN EARLY LIFE AND ITS ASSOCIATION WITH ALLERGY DEVELOPMENT. ScholarBank@NUS Repository.
Abstract: LEVERAGING A SINGAPOREAN BIRTH COHORT STUDY (GUSTO), WE EXPLORED THE DEVELOPMENT OF INTESTINAL MICROBIOTA OF HEALTHY INFANTS AND INFANTS WHO DEVELOPED CHILDHOOD ALLERGY, AND IDENTIFIED PLAUSIBLE MICROBIOLOGICAL BIOMARKERS OF ALLERGIC DISEASE. THE MATURATION OF INTESTINAL MICROBIOTA WAS MEASURED IN TWENTY-ONE ALLERGIC AND EIGHTEEN HEALTHY INFANTS DURING THE FIRST SIX MONTHS OF LIFE USING 16S RRNA SEQUENCING. PRONOUNCED DIFFERENCES IN THE INTESTINAL MICROBIOTA COMPOSITION BETWEEN ALLERGIC AND HEALTHY INFANTS WERE OBSERVED AT AGE 3 MONTHS. THE INTESTINAL MICROBIOTA OF HEALTHY INFANTS WAS PREDOMINANTLY CHARACTERIZED BY COMMENSAL BIFIDOBACTERIUM, WHILE THE INTESTINAL MICROBIOTA OF ALLERGIC INFANTS WAS MOSTLY DRIVEN BY KLEBSIELLA. IMPORTANTLY, INFANTS WITH HIGH KLEBSIELLA/BIFIDOBACTERIUM RATIO WERE 9 TIMES MORE LIKELY TO DEVELOP ALLERGY BY AGE 3 YEARS. OUR STUDY PROVIDES INSIGHTS INTO MICROBIAL SIGNATURES ASSOCIATED WITH THE DEVELOPMENT OF EARLY CHILDHOOD ALLERGY AND, IN PARTICULAR, SUPPORTS
URI: http://scholarbank.nus.edu.sg/handle/10635/143281
Appears in Collections:Master's Theses (Open)

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