Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/142830
Title: DESIGN OF PROTEIN-BASED INTRAVENOUS ARTEMETHER NANOFORMULATIONS FOR TREATMENT OF SEVERE MALARIA
Authors: YAA BOATENG-MARFO
Keywords: severe malaria, nanoparticles, artemether, human serum albumin,zein,targeted delivery
Issue Date: 20-Dec-2017
Citation: YAA BOATENG-MARFO (2017-12-20). DESIGN OF PROTEIN-BASED INTRAVENOUS ARTEMETHER NANOFORMULATIONS FOR TREATMENT OF SEVERE MALARIA. ScholarBank@NUS Repository.
Abstract: A fast-dissolving HSA-bound artemether nanoparticles and an extended-release artemether-loaded zein nanoparticles are developed and characterized in this work for treatment of severe malaria. The HSA-Art NPs of size below 50 nm, which is suitable for IV delivery as nanosuspension after reconstitution was prepared. In-vitro studies showed about 90 % of artemether in the nanoformulation dissolved within 10 min and artemether’s haemolytic effect decreased significantly from 101 to 7 %. HSA-Art NPs was stable for 40 weeks at 4 °C. 120 - 200 nm Art-loaded zein NPs with encapsulation efficiency of 31 - 62 % was prepared. Art-loaded zein NPs presented an initial release of 47 % within 15 min followed by slow release to 90.60 % in 24 h. This formulation was stable for at least 24 weeks at 4 °C and caused a significant reduction of the haemolytic effect of artemether from 101 to 6 %.
URI: http://scholarbank.nus.edu.sg/handle/10635/142830
Appears in Collections:Ph.D Theses (Restricted)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
BOATENG-MARFO Y.pdf10.27 MBAdobe PDF

RESTRICTED

NoneLog In

Page view(s)

34
checked on Sep 20, 2018

Download(s)

2
checked on Sep 20, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.