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Title: | DESIGN OF PROTEIN-BASED INTRAVENOUS ARTEMETHER NANOFORMULATIONS FOR TREATMENT OF SEVERE MALARIA | Authors: | YAA BOATENG-MARFO | Keywords: | severe malaria, nanoparticles, artemether, human serum albumin,zein,targeted delivery | Issue Date: | 20-Dec-2017 | Citation: | YAA BOATENG-MARFO (2017-12-20). DESIGN OF PROTEIN-BASED INTRAVENOUS ARTEMETHER NANOFORMULATIONS FOR TREATMENT OF SEVERE MALARIA. ScholarBank@NUS Repository. | Abstract: | A fast-dissolving HSA-bound artemether nanoparticles and an extended-release artemether-loaded zein nanoparticles are developed and characterized in this work for treatment of severe malaria. The HSA-Art NPs of size below 50 nm, which is suitable for IV delivery as nanosuspension after reconstitution was prepared. In-vitro studies showed about 90 % of artemether in the nanoformulation dissolved within 10 min and artemether’s haemolytic effect decreased significantly from 101 to 7 %. HSA-Art NPs was stable for 40 weeks at 4 °C. 120 - 200 nm Art-loaded zein NPs with encapsulation efficiency of 31 - 62 % was prepared. Art-loaded zein NPs presented an initial release of 47 % within 15 min followed by slow release to 90.60 % in 24 h. This formulation was stable for at least 24 weeks at 4 °C and caused a significant reduction of the haemolytic effect of artemether from 101 to 6 %. | URI: | http://scholarbank.nus.edu.sg/handle/10635/142830 |
Appears in Collections: | Ph.D Theses (Open) |
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