Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/142821
Title: ANIONIC MACROMOLECULAR HYDROGELS FOR ANTIMICROBIAL PEPTIDE THERAPY
Authors: SYBIL AKUA OKYEREWA OBUOBI
ORCID iD:   orcid.org/0000-0002-2905-581X
Keywords: anionic hydrogels, physical cross linking, topical wound infections, wound healing, antimicrobial peptides, sustained drug delivery
Issue Date: 18-Jan-2018
Citation: SYBIL AKUA OKYEREWA OBUOBI (2018-01-18). ANIONIC MACROMOLECULAR HYDROGELS FOR ANTIMICROBIAL PEPTIDE THERAPY. ScholarBank@NUS Repository.
Abstract: Hydrogels are an appealing class of three-dimensional hydrophilic polymeric networks with desirable physicochemical properties for numerous biomedical applications. The overall arching goal of this thesis is aimed at addressing the drawbacks of systemic peptide delivery by evaluating anionic hydrogels as potential scaffolds for the controlled delivery of cationic antimicrobial peptides against topical wound infections. We hypothesized that, rationally designed macromolecular anionic hydrogels are biodegradable/biocompatible systems for local drug delivery and that short-range non-covalent interactions between the encapsulated cationic peptides and anionic hydrogel matrix govern efficient loading and control drug release. In the first study, an array of phenylboronic acid functionalized polycarbonate copolymers are designed and developed as hydrogels for polymyxin B delivery against Pseudomonas aeruginosa infections. In the second study, deoxyribonucleic acid hydrogels were developed as potential wound dressings and evaluated as delivery matrices for synthetic 𝛼-helical peptides whilst demonstrating their responsiveness and superior antimicrobial activity against Staphylococcus aureus infections.
URI: http://scholarbank.nus.edu.sg/handle/10635/142821
Appears in Collections:Ph.D Theses (Open)

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