Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14242
Title: Investigations into the transport properties of angiotensin peptides
Authors: CHUA HUI LEE
Keywords: Angiotensin peptides, Des- Asp angiotensin I, Caco-2 cell monolayers, Transport properties, Physicochemical properties, Secondary structure
Issue Date: 28-Jul-2004
Source: CHUA HUI LEE (2004-07-28). Investigations into the transport properties of angiotensin peptides. ScholarBank@NUS Repository.
Abstract: The angiotensin peptides des-Asp - angiotensin I, angiotensin III and angiotensin IV are physiological peptides with cardioprotective properties. Angiotensins III and IV are also found in food. The transport properties of these peptides across the intestinal barrier will have a direct bearing on their prospective utility as therapeutic agents. Thus, their transport across the Caco-2 cell monolayers was investigated with a view of establishing the extent and probable route(s) of transport. The influence of physicochemical/ structural properties in influencing transport was also investigated. The results of this investigation showed different routes of transport for the angiotensin peptides with conformational characteristics playing an important role in influencing the prevailing route of transport.
URI: http://scholarbank.nus.edu.sg/handle/10635/14242
Appears in Collections:Master's Theses (Open)

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