Distributed computational intelligence applied in bioinformatics

Abstract

The use of DNA microarray allows massively parallel analysis of gene expression on tens of thousands of genes from a given sample. The success of using this technique depends on obtaining DNA probes to be printed on the array. In this research project, a technique to obtain optimized probe sets of a genome making use of computational intelligence techniques has been developed. A distributed evolutionary strategy package, Paladin-DES has been developed to search for unique and optimized probe sets. Probes of the human malaria parasite, Plasmodium falciparum, have been found using the Paladin-DES package and results are compared with other previously developed techniques. Simulation results demonstrate the capability of Paladin-DES.