Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14189
Title: Genome scale analysis of positional clustering of mouse testes-specific genes
Authors: LI QUAN
Keywords: mouse genome, gene clusters, tissue-specific genes,testes-specific genes
Issue Date: 23-Jul-2004
Source: LI QUAN (2004-07-23). Genome scale analysis of positional clustering of mouse testes-specific genes. ScholarBank@NUS Repository.
Abstract: Genes are not randomly distributed on a chromosome. The positional clustering of co-expressed genes has been known in prokaryotes (operons) and been recently described in several eukaryote organisms such as Caenorabditie elegan, Drosophila melanogaster, and Homo sapiens. According to recent studies, these clusters consist of both housekeeping genes and tissue-specific genes. In order to further investigate the mode of tissue-specific gene clustering in higher eukaryotes, we performed a genome-wide analysis of distribution of testes-specific genes on the mouse genome. Clustered genes were observed from the testes-specific gene expression profile. Our analyses showed that two-thirds of testes-specific genes were clustered in the mouse genome (2114/3449). The number of clusters is much higher than expected by chance even after removal of tandem repeats. Our result suggests that testes-specific genes tend to cluster on the mouse chromosomes. This provides strong evidence for the hypothesis that clusters of tissue specific genes do exist and might be more frequent than initially thought. This finding may result from a higher order organization of genes in the mouse genome.
URI: http://scholarbank.nus.edu.sg/handle/10635/14189
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