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https://scholarbank.nus.edu.sg/handle/10635/141703
DC Field | Value | |
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dc.title | PATHWAY TO INSULIN RESISTANCE IN HUMANS: DISSECTING THE ROLE OF ETHNICITY, FAT DEPOTS AND INTERMEDIALRY METABOLITES | |
dc.contributor.author | KHOO CHIN MENG | |
dc.date.accessioned | 2018-05-09T18:00:24Z | |
dc.date.available | 2018-05-09T18:00:24Z | |
dc.date.issued | 2017-04-07 | |
dc.identifier.citation | KHOO CHIN MENG (2017-04-07). PATHWAY TO INSULIN RESISTANCE IN HUMANS: DISSECTING THE ROLE OF ETHNICITY, FAT DEPOTS AND INTERMEDIALRY METABOLITES. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/141703 | |
dc.description.abstract | This thesis examined the obesity-dependent and obesity-independent pathways of insulin resistance (IR). Ethnicity modifies the relationship between adiposity and IR. Study 1 showed that body fat partitioning does not explain ethnicity differences in IR. Study 2 to 4 are designed to examine nutrient (in particular branched-chain amino acids, BCAA) and nutrient handling in relation to IR. Study 2 showed that physical activities but not dietary protein intake has a mild influence on circulating BCAA. A sedentary lifestyle is associated with higher circulating BCAA only in males. Study 3 showed that within two weeks, changes in circulating BCAA are already pronounced (especially in postprandial period) after Roux-en-Y gastric bypass surgery but not with caloric restriction. Study 4 showed that short-term overfeeding is metabolically harmful. High-fat diet might favour fat storage and high-carbohydrate diet shows enhanced fatty acid oxidation with depletion of Kreb cycle substrates. Metabolic changes after high-fat-plus-BCAA diet are minimal. | |
dc.language.iso | en | |
dc.subject | obesity-dependent, obesity-independent, insulin resistance, ethnicity, nutrients, nutrient handling | |
dc.type | Thesis | |
dc.contributor.department | MEDICINE | |
dc.contributor.supervisor | Tai E Shyong | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY (SOM) | |
dc.identifier.orcid | 0000-0002-1549-8273 | |
Appears in Collections: | Ph.D Theses (Open) |
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KHOOCM2.pdf | 4.43 MB | Adobe PDF | OPEN | None | View/Download |
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