Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14039
Title: Role of oestrogens in male erectile function
Authors: SRILATHA BALASUBRAMANIAN
Keywords: oestradiol, phytoestrogen, oestrogen receptors, erectile dysfunction, testosterone, corpus cavernosum
Issue Date: 14-Jun-2004
Source: SRILATHA BALASUBRAMANIAN (2004-06-14). Role of oestrogens in male erectile function. ScholarBank@NUS Repository.
Abstract: Longitudinal age trends in testosterone decline together with an oestrogenic negative feedback on gonadotropins via receptors in the pituitary and hypothalamus may cause significant endocrine disruption of sexual function; inadvertent exposure to oestrogenic activity from the environment is likely to pose similar challenge. In this investigation, long term oestradiol (E2) treatment (12 weeks) precipitated sexual behavioural deficits and significantly reduced intracavernous pressure response to erectile nerve stimulation in the rat model. These changes correlated directly with two to five folds elevation in serum E2 levels (and simultaneous reduction in T levels). Pretreatments with E2 and phytoestrogen daidzein impaired neurotransmitter mediated erectile function in rabbits seen as reduced relaxant responses to acetylcholine, nitroglycerine and nitrergic transmission and significantly potentiated noradrenaline induced antierectile contraction of the cavernosum. Histologically, trichrome staining highlighted the cavernosal connective tissue hyperplasia and decrease in smooth muscle in both models and in tissue culture studies, the cyclic guanosine monophosphate release was impaired by oestradiol. Exploratory immunohistochemistry proposed a genomic basis for these effects through positive signals for nuclear ERi?! and ERi?? receptors within the rabbit cavernosum. Hormone profile data of ED patients from this centre gave the clinical correlate for the experimental results. This investigation indicates that both oestradiol and phytoestrogen cause pathophysiological challenges to normal erectile function and highlights the endocrine disruptive effect of oestrogens including their negative impact on T levels on male sexual health.
URI: http://scholarbank.nus.edu.sg/handle/10635/14039
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