Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13994
Title: Characterisation of the role of bifocal and its interacting partners in Drosophila development
Authors: KAVITA BABU
Keywords: Drosophila, eye development, axon guidance, oogenesis
Issue Date: 22-Jun-2004
Source: KAVITA BABU (2004-06-22). Characterisation of the role of bifocal and its interacting partners in Drosophila development. ScholarBank@NUS Repository.
Abstract: The work described in this thesis deals with the characterisation of the role of an actin binding protein, Bifocal, and its interacting partners during various stages of development of the model organism Drosophila melanogaster. The results are described in three chapters.Chapter 3 deals with the interaction between Bifocal and Protein Phosphatase 1 (PP1) and the in vivo requirement of this interaction for normal eye development. In chapter 4, I describe the photoreceptor axon guidance phenotype seen in bif mutants. This function of Bif in photoreceptor axon guidance also requires the interaction between Bif and PP1. This chapter also describes the axon guidance defects seen in PP1 mutants and the interaction between Bif and other phosphatases. Chapter 5 describes the genetic interaction between Bif and Homer (Hom). The bif; hom double mutant flies show defects in anchoring Osk to the posterior cortex of the oocyte. Further, experiments using drugs to destabilise the F-actin cytoskeleton lead to the conclusion that there may be F-actin dependent and F-actin independent mechanisms, either of which is required to anchor Osk to the posterior cortex of the oocyte.
URI: http://scholarbank.nus.edu.sg/handle/10635/13994
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