Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13923
Title: Role of cholesterol and cholesterol oxidation products in kainate-induced neuronal injury
Authors: GOH WEE SING,EUGENE
Keywords: Cholesterol, Cholesterol oxidation products, Neurodegeneration, Kainate, Neurotoxicity, Hippocampus
Issue Date: 16-Jun-2004
Source: GOH WEE SING,EUGENE (2004-06-16). Role of cholesterol and cholesterol oxidation products in kainate-induced neuronal injury. ScholarBank@NUS Repository.
Abstract: Cholesterol is an essential building block of mammals. In the past decade, studies have shown that cholesterol oxidation products (COPs) may possess several adverse biological effects, such as cytotoxicity, atherosclerosis and mutagenicity. The present study was carried out to elucidate the distribution of cholesterol and COPs in the hippocampus after kainate injections and to determine whether COPs are associated with neurodegenerative processes in kainate-induced neurotoxicity. In addition, the toxicity of COPs was also studied in hippocampal slice cultures. A method is presented for the extraction and quantification of cholesterol and COPs in the degenerating rat brain by gas chromatography-mass spectrometry.
URI: http://scholarbank.nus.edu.sg/handle/10635/13923
Appears in Collections:Master's Theses (Open)

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