Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/139067
Title: EXPLORING THE MECHANISMS OF SYNAPTOTROPIC ARBOR GROWTH IN DRASOPHILA
Authors: WILLIAM DUNCAN CONSTANCE
Keywords: Neurexin, Neuroligin, Synapse, Axon, Arbor, Growth
Issue Date: 12-Dec-2016
Citation: WILLIAM DUNCAN CONSTANCE (2016-12-12). EXPLORING THE MECHANISMS OF SYNAPTOTROPIC ARBOR GROWTH IN DRASOPHILA. ScholarBank@NUS Repository.
Abstract: Building arborisations of the right size and shape is fundamental to neural network function. Live imaging performed on vertebrate brains has lent support to the synaptotropic hypothesis of arbor growth, by which synapses play a key role in arbor construction through the stabilisation exploratory processes. The molecular mechanisms underlying this are largely unknown. Here I have developed a novel system for exploring this mode of growth in Drosophila. In this system I see a correlation between the distribution of synaptic puncta and branch growth reminiscent of synaptotropic growth seen in vertebrates. These puncta however do not appear to represent functional synapses and are not paired with post-synaptic receptors. Genetic or pharmacological disruptions do not affect arbor growth. Instead I find that growth is driven by dynamic localisations of synaptic components which operate by providing stability to growing branches entirely independently of synaptic transmission.
URI: http://scholarbank.nus.edu.sg/handle/10635/139067
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