Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13905
Title: Ethnic variation in breast cancer in Singapore
Authors: LI YUQING
Keywords: Breast cancer, Incidence, Risk factors, Ethnic groups, Menopause status, Case-control study, Leptin, Leptin receptor
Issue Date: 3-May-2004
Source: LI YUQING (2004-05-03). Ethnic variation in breast cancer in Singapore. ScholarBank@NUS Repository.
Abstract: Breast cancer is the most common cancer in women in Singapore. In Part I research work, we analyzed the ethnic difference changes of breast cancer incidence in last three decades, 1968-1997, among Chinese, Malays and Indians resident in Singapore. Statistics data was obtained from the Singapore Cancer Registry. We also conducted a hospital based case-control study to explore possible risk factors of breast cancer. In the results, we showed that all three ethnic groups had an increase in incidence of breast cancer over the past three decades. The greatest increase is in the Malay group. The Chinese group has the highest pre-menopausal breast cancer incidence, while Indian women has the highest post-menopausal incidence. We also found that all three ethnic groups share a common subset of some risk factors for breast cancer. But some other subsets of factors related to breast cancer such as, cycle length of menses period, menopause status, age of first marriage, number of full term pregnancies, age at first pregnancy and oral contraceptive use are distinguishable between the three ethnic groups. These factors may help to provide an explanation for different patterns for incidence rates of breast cancer. In Part II, we delineated that the role of leptin on mammary carcinoma cell line proliferation is mediated by the specific leptin receptor in vitro. Human leptin was discovered in 1994 and has been described to be produced by adipose tissue. We found that leptin receptor is expressed on breast cancer cell line (MCF-7) and it can be activated by leptin in Mitogen-activated protein (MAP) kinase pathway. cDNA microarray is used to investigate other leptin effects on the MCF-7 breast cancer cell line. In conclusion, leptin receptor exists in human breast cancer cell and through cella??s specific leptin receptor; leptin has the function of stimulating cell proliferation.
URI: http://scholarbank.nus.edu.sg/handle/10635/13905
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