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Title: Atomic force microscope imaging of human red blood cells and theri mechanical properties
Authors: WU TAO
Keywords: AFM, RBC, cytoskeleton network, force-distance curve, Young’s modulus, micro-rheology
Issue Date: 19-Mar-2004
Source: WU TAO (2004-03-19). Atomic force microscope imaging of human red blood cells and theri mechanical properties. ScholarBank@NUS Repository.
Abstract: Topographical imaging and force imaging by the Atomic Force Microscopy (AFM) has been applied on three kinds of human Red Blood Cells (RBC) -- dehydrated RBC, swollen RBC, and fresh RBC in PBS solution. High resolution images of RBC have been used to compare the different RBC morphology resulting from different treatment. Taking Force Volume data and the Hertz model, Younga??s modulus of different parts of these three types of RBC has been calculated and compared with those reported in earlier studies. By using proper scanning strategy, the micro-rheological properties of the RBC have also been studied. The RBCa??s inhomogeneous deformation characteristics resulted from its different local mechanical properties. More detailed understanding and interpretation for the RBCa??s deformation properties can be acquired when the cell is subject to mechanical forces in vivo.
Appears in Collections:Master's Theses (Open)

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