Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/138660
Title: TRP CHANNELS IN BROWN AND WHITE ADIPOGENESIS: NEW THERAPEUTIC TARGETS FOR METABOLIC DISEASES TREATMENT
Authors: ANNA GRAZYNA GORALCZYK
ORCID iD:   orcid.org/0000-0002-0808-4179
Keywords: brown adipocyte, browning, TRP channels, menthol, aminoglycoside, TRPM8
Issue Date: 4-Aug-2017
Citation: ANNA GRAZYNA GORALCZYK (2017-08-04). TRP CHANNELS IN BROWN AND WHITE ADIPOGENESIS: NEW THERAPEUTIC TARGETS FOR METABOLIC DISEASES TREATMENT. ScholarBank@NUS Repository.
Abstract: Activation of brown adipocytes (BA) and white adipocytes (WA) transdifferentiation are currently being explored as means to clinically manage metabolic disorders. Transient Receptor Potential (TRP) channels are polymodal cell sensors widely implicated in cellular differentiation. I provided evidence for the differential expression of TRP channels during in vitro white or brown adipogenesis. Two TRPs were found to be developmentally expressed during human adipogenesis: TRPP3, for the first time implicated in brown adipogenesis and TRPM8, previously reported in adipocytes, but my findings are the first, to ascribe it a role in brown adipogenesis. I showed that TRPM8 is an upstream effector in the conversion of WA toward a BA-like phenotype and both TRPM8 and TRPP3 are involved in BA differentiation. My data suggest that both TRPs act at the level of mitochondrial respiration, having little impact on generalized adipogenic phenotype. Thus, both channels represent targets for therapeutic intervention of metabolic disorders.
URI: http://scholarbank.nus.edu.sg/handle/10635/138660
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