Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13834
Title: Studies of regulation of the actin cytoskeleton organization and endocytosis in Saccharomyces cerevisiae
Authors: LIU JUN
Keywords: actin cytoskeleton, endocytosis, protein kinase, phosphorylation, protein phosphatase, [L/I]xxQxTG motif
Issue Date: 12-Apr-2004
Source: LIU JUN (2004-04-12). Studies of regulation of the actin cytoskeleton organization and endocytosis in Saccharomyces cerevisiae. ScholarBank@NUS Repository.
Abstract: The serine/threonine kinase Prk1p is a key regulator of the actin cytoskeleton organization and endocytosis in yeast Saccharomyces cerevisiae and the kinase phosphorylation motif is [L/I]xxQxTG. Bee1p contains one LxxQxTG motif and is required for the actin cytoskeleton organization and endocytosis. On the other hand, the phosphatase Glc7p was found to interact with Sla1p and Pan1p (two Prk1p substrates) respectively in vitro. All these facts led us to investigate whether Bee1p exerts its function under the regulation of Prk1p; and whether Glc7p would be the antagonist of Prk1p on the functions of Pan1p module. However, my studies suggested that Prk1pa??s regulation on the functions of Bee1p, if there were any, would not be important; and Glc7p may not function antagonistically with Prk1p on regulation of actin cytoskeleton organization or endocytosis.
URI: http://scholarbank.nus.edu.sg/handle/10635/13834
Appears in Collections:Master's Theses (Open)

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