Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/138195
Title: ASSOCIATIVE PLASTICITY IN HIPPOCAMPAL CA2 PYRAMIDAL NEURONS AND ITS IMPLICATIONS IN MEMORY NETWORKS
Authors: ANANYA DASGUPTA
Keywords: Synapse, LTP, Synaptic tagging/capture, CA2, Substance P, mGluR4
Issue Date: 10-Aug-2017
Source: ANANYA DASGUPTA (2017-08-10). ASSOCIATIVE PLASTICITY IN HIPPOCAMPAL CA2 PYRAMIDAL NEURONS AND ITS IMPLICATIONS IN MEMORY NETWORKS. ScholarBank@NUS Repository.
Abstract: Hippocampus is a brain region responsible for the formation of spatial memories, facts and events. It is only recently that a small area of hippocampus, area CA2, has been identified as a critical brain region for the formation of social memory and interaction. This region displays unique molecular, structural and physiological properties and receives multiple intra- and extra-hippocampal neuromodulatory inputs. Although entorhinal cortical (EC) inputs to CA2 display long-term potentiation (LTP), a type of synaptic plasticity underlying memory formation, the Schaffer collateral (SC) inputs to CA2 are apparently resistant to it. In the present study, we provide evidence that LTP can be induced in SC either by using a specific neuromodulator Substance P (SP) or by inhibitors of localized metabotropic glutamate receptors. In addition, SC plasticity could associate with EC weak memory traces to form long-term memory (synaptic tagging/capture). Understanding the cellular mechanisms of plasticity and associativity processes in CA2 may account for the future therapeutic interventions for socio-cognitive and emotional decline in various neurological disorders such as depression, schizophrenia, epilepsy and autism.
URI: http://scholarbank.nus.edu.sg/handle/10635/138195
Appears in Collections:Ph.D Theses (Open)

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