Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/138178
Title: AN ANISOTROPIC AND VASCULARIZING CELL-SEEDED PATCH FOR MYOCARDIAL REGENERATION
Authors: MARIA CHRISTINE TANKEH ASUNCION
ORCID iD:   orcid.org/0000-0001-9163-0953
Keywords: silk fibroin, tissue engineering, microparticles, cardiac tissue engineering, vegf delivery, unidirectional freezing
Issue Date: 16-Aug-2017
Source: MARIA CHRISTINE TANKEH ASUNCION (2017-08-16). AN ANISOTROPIC AND VASCULARIZING CELL-SEEDED PATCH FOR MYOCARDIAL REGENERATION. ScholarBank@NUS Repository.
Abstract: As cardiovascular diseases remain to be a leading cause of death worldwide, different strategies are currently being explored as alternatives to heart transplantation. Due to the limited clinical success of cellular strategies and the higher risks involved in genetic therapies, the possibility of using cardiac tissue engineering to surgically restore heart function remains to be noteworthy of investigation. In this study, undirectional freezing was used to construct a silk-based cardiac patch to address the need for anisotropy to match native cardiac tissue. VEGF-loaded silk microparticles were incorporated to the patch as a vascularization strategy to attain a clinically-relevant thickness and finally, induced porcine bone marrow-derived mesenchymal stem cells were seeded into the growth factor-releasing scaffold. The resulting construct was an anisotropic and VEGF-releasing cell-seeded patch that could be used as a foundation for future in vivo studies in myocardial regeneration.
URI: http://scholarbank.nus.edu.sg/handle/10635/138178
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
AsuncionMCT.pdf8.25 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

8
checked on Jan 14, 2018

Download(s)

1
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.