Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/138169
Title: EXPLORATION OF THE ROLE OF STRONTIUM IN BONE HEALTH AND AS A TOOL TO MONITOR CHANGES IN BONE CALCIUM METABOLISM USING ISOTOPE TRACING TECHNIQUES
Authors: JI XIANG
Keywords: Strontium, Stable isotope, Sub-therapeutic, Bone, Calcium metabolism, Tracing technique
Issue Date: 19-Jan-2017
Source: JI XIANG (2017-01-19). EXPLORATION OF THE ROLE OF STRONTIUM IN BONE HEALTH AND AS A TOOL TO MONITOR CHANGES IN BONE CALCIUM METABOLISM USING ISOTOPE TRACING TECHNIQUES. ScholarBank@NUS Repository.
Abstract: The aim of this thesis is to evaluate whether strontium intake with the amount well below therapeutic levels can have a detectable effect on bone and if strontium can be used for studying calcium metabolism in humans as well as to assess the response of bone to interventions. The long-term effect of sub-therapeutic dosage of strontium on bone was investigated in adult male Wistar rats. We found that strontium had a positive influence on bone at doses as low as 16% of the effective therapeutic dose of strontium ranelate with negligible risk of tissue hardening by strontification. The usefulness of a stable strontium isotope as a surrogate tracer in monitoring calcium metabolism was evaluated in this thesis. It was found that labeling of the skeleton and measuring urinary excretion of the tracer can be used as a diagnostic tool for early detection of evolving impairments in calcium and bone metabolism.
URI: http://scholarbank.nus.edu.sg/handle/10635/138169
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