Please use this identifier to cite or link to this item: https://doi.org/10.1080/15592294.2017.1281502
Title: A drive in SUVs: From development to disease
Authors: Rao, Vinaykumar
Pal, Ananya
RESHMA TANEJA 
Keywords: Cancer
cell cycle
chromatin modifiers
differentiation
gene regulation
heterochromatin
histones
methylation
Cell Cycle
Cell Differentiation
Chromatin Assembly and Disassembly
DNA Methylation
Gene Expression Regulation
Heterochromatin
Histones
Humans
Methyltransferases
Neoplasms
Repressor Proteins
Epigenesis, Genetic
Issue Date: 4-Mar-2017
Publisher: Taylor and Francis Inc.
Source: Rao, Vinaykumar, Pal, Ananya, RESHMA TANEJA (2017-03-04). A drive in SUVs: From development to disease. Epigenetics 12 (3) : 177-186. ScholarBank@NUS Repository. https://doi.org/10.1080/15592294.2017.1281502
Abstract: Progression of cells through distinct phases of the cell cycle, and transition into out-of-cycling states, such as terminal differentiation and senescence, is accompanied by specific patterns of gene expression. These cell fate decisions are mediated not only by distinct transcription factors, but also chromatin modifiers that establish heritable epigenetic patterns. Lysine methyltransferases (KMTs) that mediate methylation marks on histone and non-histone proteins are now recognized as important regulators of gene expression in cycling and non-cycling cells. Among these, the SUV39 sub-family of KMTs, which includes SUV39H1, SUV39H2, G9a, GLP, SETDB1, and SETDB2, play a prominent role. In this review, we discuss their biochemical properties, sub-cellular localization and function in cell cycle, differentiation programs, and cellular senescence. We also discuss their aberrant expression in cancers, which exhibit de-regulation of cell cycle and differentiation.
Source Title: Epigenetics
URI: http://scholarbank.nus.edu.sg/handle/10635/137821
ISSN: 15592294
DOI: 10.1080/15592294.2017.1281502
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